Only your healthcare professional can diagnose your disorder and decide which treatment option is best for you. Researchers have sought to compare Wellbutrin and Lexapro both as singular therapy for MDD, as well as dual therapy.
One trial evaluated the efficacy of Wellbutrin as single therapy as compared to Lexapro single therapy. This study also sought to compare the prevalence of negative sexual side effects. The results found that Wellbutrin and Lexapro produced similar improvements in depressive symptoms, however, Wellbutrin was significantly less likely to cause sexual dysfunction.
Wellbutrin and Lexapro affect different neurotransmitters and are oftentimes used together. The results of one clinical trial found that the use of both drugs together leads to significantly higher response and symptom remission rates as compared to typical monotherapy with SSRIs. While further studies may be warranted, this study suggests some value in dual therapy with both medications. Sign up for Wellbutrin price alerts and find out when the price changes!
Wellbutrin is a prescription medication that is typically covered by both commercial and Medicare drug plans. Lexapro is also a prescription medication that is typically covered by both commercial and Medicare drug plans. Try the SingleCare prescription discount card.
Wellbutrin and Lexapro affect the levels of different neurotransmitters. While their potential to cause certain side effects may be similar, there are some key differences. Lexapro, like other SSRIs, has the potential to cause decreased libido or sex drive. Wellbutrin had no reported incidence of decreased libido. Wellbutrin causes headache in as much as a quarter of the patients who take it, while headaches were not reported with Lexapro.
Wellbutrin and Lexapro both may cause nausea, vomiting, sweating, and diarrhea. The following list is not intended to be a complete list of adverse events. Please consult a pharmacist, doctor, or another medical professional for a complete list of possible side effects.
If co-administration of Wellbutrin and a CYP2D6 substrate is needed, it may be necessary to decrease the dose of the 2D6 substrate. Some examples of CYP2D6 substrates include fluoxetine, sertraline, haloperidol, risperidone, and metoprolol. The use of Lexapro with tricyclic antidepressants, such as amitriptyline, may increase the risk of QT prolongation and serotonin syndrome.
In general, this combination should be avoided. The following list is not intended to be a complete list of drug interactions. It is best to consult your provider or pharmacist for a complete list. Patients with MDD may experience a worsening of depression or suicidal thoughts whether or not they are taking antidepressant medications.
These conditions may worsen until remission is achieved. Wellbutrin and Lexapro therapy may increase suicidal ideation and thoughts among teens and young adults, especially in the early stages of treatment before any type of remission is achieved. These patients must be monitored closely if this treatment is deemed medically necessary.
A therapy change may be necessary if symptoms suddenly arise or get worse. Patients taking bupropion products for smoking cessation and who have no previous history of depression, may experience mental changes when they initiate therapy. These can include mood changes, hallucinations, paranoia, delusions, aggression, and anxiety.
If this occurs, speak with your healthcare provider immediately. In the case of both Wellbutrin and Lexapro, depression symptoms do not start to resolve immediately. Typically, changes in symptoms take a minimum of two weeks to observe, with most patients needing at least four to six weeks to see if the drug is having an impact on their symptoms.
Wellbutrin can increase the risk of seizure. This increased risk is dose-dependent, and the maximum total daily dose should not exceed mg.
Wellbutrin may also be responsible for increased cardiovascular events. Patients on Wellbutrin may experience increased blood pressure, leading to hypertension, even if they had no previous cardiovascular diagnoses. This is a condition related to abnormally high levels of serotonin and can result in the patient feeling agitated, dizzy, and having an increased heart rate.
This can be brought on by the use of two serotonergic drugs together. Wellbutrin is a prescription antidepressant medication. In that note, it is advised that the patient should avoid any activities that require mental alertness or involve handling hazardous machinery until it can be ascertained for sure how the medications affect them.
Combination of Wellbutrin and Adderall lead to a major interaction which is heavily influenced by the strength of the doses — particularly the Adderall dose. Excessive use of psychostimulants in itself already poses a significant risk to the health of the patient, and using it alongside bupropion is likely to be the final trigger that tips them over into experiencing seizures.
CNS stimulants such as Vyvanse Lisdexamfetamine also lead to a major drug interaction with bupropion. The risk of seizures is increased with concurrent use, so extreme caution and close monitoring are strongly recommended if they have to be taken together.
Ritalin Methylphenidate is a drug that may lower the seizure threshold of a user, so it must be used with extreme caution and close guidance. If it must be used with bupropion, manufacturers recommend starting with a tiny dose and slowly titrating up to the minimum effective dose, while the patient is closely monitored. Additionally, while the patient is slowly increasing doses of Ritalin, attempting to wean off bupropion slowly could be helpful too. Using Wellbutrin and tramadol together leads to a major drug interaction.
First of all, the concurrent administration of bupropion to a patient that is dosing on tramadol can affect the analgesic effects that the tramadol is supposed to have in the body. Secondly, for a drug like bupropion that reduces the seizure threshold, the administration of tramadol with bupropion can increase the risk of spasms. Kratom is known to have HT2a antagonistic effects.
This would reduce GABA upregulation, increasing the risk of convultions when used at the same time with a drug like bupropion that reduces the seizure threshold, the chances of the patient having a seizure is increased — even more so if the patient is already dealing with medical conditions that affect the central nervous system. Patients that already have pre-existing seizure disorders are advised to steer clear of bupropion. Additionally, bupropion may interact pharmacokinetically with anticonvulsant medication that triggers hepatic microsomal isoenzyme function.
For the same reasons as are stated here, it is inadvisable to use Wellbutrin and Topamax together. Using Abilify Aripiprazole and Wellbutrin together can lead to a major drug interaction. Because Aripiprazole is partially metabolized by CYP2D6, manufacturers recommend that patients using the drug alongside bupropion or similar drugs should reduce the Aripiprazole dose to one-half of the usual dose.
Then, the patient must be closely monitored. Patients that have seizure disorders are advised to keep away from Wellbutrin, as well as take Gabapentin medication , as it tends to reduce the seizure threshold, increasing the risk of spasms.
Some antidepressants are known to hurt the sexual life of the user. While bupropion sexual side effects are relatively mild , it would still be counter-productive to use the drug while treating erectile dysfunction with Viagra.
Excessive use of the psychostimulant, Phentermine may be associated with an increased risk of seizures. Therefore, it is inadvisable to use the drug alongside bupropion due to its seizure threshold-reducing characteristics.
Wellbutrin may trigger an increase in the blood pressure level and side effects of Benadryl Diphenhydramine in the body. If they must be used together, there should be a dose adjustment done by health professional along with close monitoring during the treatment process.
Patients are usually advised to steer clear of marijuana when using drugs such as bupropion, especially when starting the treatment. This is because, just like other psychoactive substances, marijuana may interfere with the effects of antidepressants on the central nervous system.
Also, it makes it hard to determine if the medication is working or if a patient is experiencing side effects. As suggested earlier, psychostimulants increase the risk of seizures when used alongside bupropion.
Taking Wellbutrin and wine or other alcohol together will lead to harmful drug interactions. Alcohol is widely known for increasing the risk of side effects to appear in most drugs, and the case here is no different. Lexapro does carry the risk of premature birth when taken in the second and third trimesters of pregnancy. You, your doctor, or a Minded professional will need to balance these risks with the potential benefits of Lexapro, including your health during pregnancy.
You should avoid drinking alcohol while taking Lexapro. Some people find that an overly restrictive suggestion; for those who do, talk to your doctor or a Minded professional for information about using alcohol in small quantities. Some significant drugs to pay attention to are antipsychotics, SSRIs, blood thinners, or lithium. Please be aware that suddenly stopping your use of Lexapro can produce withdrawal symptoms, so it is best to slowly reduce its dose, as advised by your doctor.
Withdrawal symptoms may include headache, agitation, mood swings, and difficulty concentrating. There is no clear-cut answer in choosing between Lexapro and Wellbutrin. That is because each person is different, with potentially different responses and sensitivities to a medication.
Both drugs have been effective in depressed patients. Your choice will be more informed by the information here, as well as speaking with your doctor or a Minded professional about any difference in favor of one or the other, as well as if SSRIs or NDRIs are likely to be a better choice for you.
Your medication goals, in addition to treating your depression, like reducing anxiety or curbing your smoking, can help you choose between Lexapro vs Wellbutrin. Your doctor might also suggest using one or the other to help with other, off-label conditions. Wellbutrin can have fewer side effects, especially not producing reductions in libido and sexual dysfunction. In one clinical trial , Wellbutrin had fewer sexual side effects than other antidepressants, including Lexapro. But if you have medical conditions in addition to depression, or a history of specific illnesses in your family, Wellbutrin may not be the right choice for you; this is important to discuss with your doctor in order to minimize any serious side effects or reactions.
In terms of pregnancy, neither medication is considered fully safe since neither have had enough human studies to ensure their safety. But the FDA does categorize Wellbutrin in a more secure class than Lexapro, so it is potentially safer for use in those who are pregnant. Both antidepressants can help with postpartum depression , quite common, especially in those with a history of depression.
Recall, as noted above, that both pass in the breast milk to the nursing child. Be sure to talk to your doctor about the risks of using Lexapro vs Wellbutrin if breastfeeding your infant.
Is Lexapro better than Wellbutrin, or does Wellbutrin work better than Lexapro? And we know that Wellbutrin carries more risk if you are prone to seizures. Taking the time to consider these matters with your doctor can make a considerable difference in your reaction to either medication.
Clinical studies have shown that taking Wellbutrin and Lexapro together can produce beneficial results. Combining Wellbutrin and Lexapro together can improve symptoms in depressed patients. Talk to your doctor or a Minded expert to find out if the combination might work for you.
They also have other uses, like Wellbutrin aiding smoking cessation and Lexapro helping anxiety. Both medications have strengths and weaknesses. When deciding if Wellbutrin bupropion vs Lexapro escitalopram is better, seek the medical advice of your health care provider to determine which one may best serve your needs.
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